Hearing Science Lab

Director: Anthony Cacace, Ph.D.


Dr. Anthony T. Cacace, Professor and Director of the Hearing Science Laboratory, conducts audiological/neuroscience research and is an expert in the areas of cen-tral auditory processing disorder (CAPD), tinnitus, and novel methodologies for as-sessment of hearing loss, vestibular disorders, and brain-related dysfunctions. He has published a new book in 2016 entitled, “Scientific Foundations of Audiology: Perspectives from Physics, Biology, Modeling, and Medicine” with colleagues Drs. Emile de Kleine, Avril Genene Holt, & Pim vanDijk. It covers advanced topics perti-nent to audiology and hearing science with the underlying premise that the audiolo-gist is the translational interface between basic science and clinical concerns and represents the best person to apply scientific breakthroughs in molecular biology, genetics, medicine, engineering, neuroimaging, etc., and implement them in the clinic to advance the field. He is also interested in developing the use of hearing simulators and contemporary vestibular testing for student education and research. In this context, he has received over $64,000 in CLAS Omnibus grants over the last 4 years to move forward with these initiatives.
Dr. Cacace is currently working on several NIH and VA-funded research grants focusing on (1) vagus nerve stimu-lation and tinnitus suppression based on a targeted neuroplasticity framework in humans, (2) in applying novel ther-anostic approaches to identify and treat tinnitus using functionalized nanoparticles, (3) in developing other effective strategies for tinnitus diagnosis and treatment in animal models, and (4) in assessing the effects of blast exposure and noise on vestibular system function in humans and animals.

 

More about:

Anthony T. Cacace, Ph.D.

Fellow American Language and Hearing Association

Fellow American Academy of Audiology

 

Professional Interests: 

Dr. Cacace is Professor of Audiology, in the Department of Communication Sciences & Disorders at Wayne State University. Prior to this position at Wayne State University, he was full time tenured faculty at Albany Medical College, Albany, NY within the Department of Surgery. At different points in his career, he headed the Audiology Department and Hearing Rehabilitation Center at Albany Medical Center Hospital and was also Director of Oto-neurological Research within the Division of Otolaryngology, Albany Medical College. He then transitioned to the Department of Neurology, and was faculty with the Neurosciences Institute and the Center for Neuroscience Research.

He is an expert in the areas of psychoacoustics, electroacoustics, electrophysiology, vestibular and balance assessment, repetitive transcranial magnetic stimulation and various magnetic resonance neuroimaging procedures. His current focus includes the study of Central Auditory Processing Disorder, tinnitus, effects of noise on vestibular and balance system and gait related issues. He is a co-investigator and co-principal investigator on funded research studies through the Veteran’s Administration and the Department of Defense studying the vestibular consequences of blast injuries, blast and concussion-induced tinnitus, and noise induced vestibular dysfunction.

He teaches courses on medical issues, auditory processing disorders, tinnitus, research methods and design. He is the primary supervisor for Capstone projects within the department.

Current work:

He is currently funded by grants from the National Institutes of Health, the Veteran’s Administration, and has also received funding from the Department of Defense.

 

Course Offerings:

AUD 8350-001 Research Seminar 1

AUD 8350-002 Research Seminar 2

AUD 8350-003 Research Seminar 3

AUD 8440-001 Medical Issues: Tinnitus, Central Auditory Processing

Doctoral Seminar

 

Education and Training:

EDUCATION:

B.S.     1974                State University of New York at New Paltz, New Paltz, New York                                               

                                        Major: Speech Pathology/Audiology.

M.S.    1975                Syracuse University, Syracuse, New York.

                                         Major: Audiology.

Ph.D.   1988               Syracuse University, Syracuse, New York.

                                        Major: Communication Sciences and Disorders/Audiology.

                                        Minor: Neuroscience

Dissertation:   "Some Poststimulatory Effects in the Acoustic Stapedius

                        Reflex: Monotic and Dichotic Stimulation".

Postdoctoral Fellowship, Neurophysiology, The Wadsworth Center for Laboratories and Research, Central Nervous System Study Section, New York State Health Department, Albany, New York, December. 1985 June 1987, 

Sponsor for Post-Doctoral Fellowship Studies: Professor Jonathan R. Wolpaw, M.D. 


PROFESSIONAL EXPERIENCE:

August 2007-present              Full Professor with tenure. Department of Communication Sciences & Disorders, Wayne State University, Detroit, Michigan.                                   

July 2003-August 2007          The Neurosciences Institute and Advanced Imaging Research Center, Department of Neurology, Albany Medical College, Albany, New York, 12208

December 1985-2003              Director of Oto‑neurological Research, Division of Otolaryngology,

                                                Albany Medical College, Albany, New York.

July 1993-June 2003              Associate Professor with Tenure, Department of Surgery,                                      

                                                  Division of Otolaryngology, Albany Medical College, Albany, New

                                                York, 12208.

June 1987‑1994                      Director Audiology, Albany Medical Center Hospital.

December 1985                       Assistant Professor, Department of Surgery (Otolaryngology), Albany Medical College, Albany, New York

September 1982‑                 Graduate Research Assistant, Hearing Science Laboratory November 1985 and Clinical Supervisor (Audiology), Gebbie                                                   Speech and Hearing Clinic, Syracuse University, Syracuse, New York.

March 1978‑June 1985           Lecturer in Education, College of St. Rose, Department of December Communication Disorders, Albany, New York.

November 1977‑                     Audiologist‑Coordinator, Hearing Rehabilitation Center,

June 1982                                Albany Medical Center Hospital, Albany, New York.

September 1977‑1982             Consultant in Audiology, August 1982 Berkshire Ears, Nose, and Throat Associations. Pittsfield, Massachusetts.

July 1976‑August 1982          Staff Audiologist, Albany Medical Center Hospital

                                                Albany, New York.

 

September 1975-                     Clinical Fellowship (Audiology), Albany Medical Center

August 1976                           Hospital,  Albany, New York.

Published Books:

  • Langguth, B., Hajak, G, Kleinjung T, Cacace, A.T., and Møller, A.R. (Editors). Tinnitus: Pathophysiology and Treatment. Progress in Brain Research. Elsevier (2007).
  • Cacace, A.T., and McFarland, D.J. (Editors), Controversies in Central Auditory Processing Disorder. San Diego: Plural Publishing (2009).
  • Cacace, A.T., de Kleine, E., Holt, A. G., van Dijk, P. (Editors), Scientific Foundations of Audiology: Perspectives from physics, biology, modeling, and medicine. San Diego: Plural Publishing (2016).

Published Book Chapters (since 2007):

  • Cacace, A.T., and McFarland, D.J. Frequency domain analysis of event related potentials and oscillations. In: Evoked Potentials: Basic Principles and Clinical Application. In: R.F. Burkard, M. Don, and J.J. Eggermont (eds). Pp. 124-137, Lippincott, Williams, & Wilkins (2007).
  • Cacace, A. T., and Silver, S. M. Applications of magnetic resonance spectroscopy to tinnitus research: Initial data, current issues, and future perspectives. In: B. Langguth, G. Hajak, T. Kleinjung, A.T. Cacace, and A. Møller, editors. Tinnitus: Pathophysiology and Treatment. Progress in Brain Research. Elsevier, 166: 71-81 (2007).
  • B. Langguth, R. Goodey, A. Azevedo, A. Bjorne, A. Cacace et al. Consensus for tinnitus patient assessment and treatment outcome measurement. In: B. Langguth, G. Hajak, T. Kleinjung, A.T. Cacace, and A. Møller, editors. Tinnitus: Pathophysiology and Treatment. Progress in Brain Research. Elsevier, 166: 525-536 (2007).
  • Tyler, R. S., Tao, P., and Cacace, A. T. The neural mechanisms of tinnitus. In: Tyler, R. S. (Editor), The Consumer Handbook of Tinnitus, pp. 31-47. Sedona, AZ: Auricle Ink Publishers (2008).
  • McFarland, D.J., and Cacace, A. T. Modality Specificity and Auditory Processing Disorders, In: Cacace, A. T., and McFarland, D. J. (Editors), Controversies in Central Auditory Processing Disorder. San Diego: Plural (2009).
  • McFarland, D.J., and Cacace, A. T. Towards the Development of Models, Theories, and Test Paradigms in Evaluating and Diagnosing Central Auditory Processing Disorder (CAPD). In: Cacace, A. T., and McFarland, D. J. (Editors), Controversies in Central Auditory Processing Disorder. San Diego: Plural (2009).
  • Cacace, A. T., and Burkard, R.F. Auditory neuropathy: Bridging the gap between basic research and current clinical concerns. In: Cacace, A. T., and McFarland, D. J. (Editors), Controversies in Central Auditory Processing Disorder. San Diego: Plural (2009).
  • Cacace, A.T., and McFarland, D.J. Middle latency auditory evoked potentials: Basic issues and potential applications. In: J. Katz, editor, Handbook of Clinical Audiology, 6th Edition, (2009).
  • May, J., Ramchandran, V., and Cacace, A. T. Tinnitus and vestibular schwannoma: Overview and clinical correlations. In: A. R. Møller, D. DeRidder, B. Languth (Editors). Textbook of Tinnitus, Humana-Springer (2011).
  • Cacace, A. T., and Burkard, R. F. What is auditory neuropathy? Translational studies that distinguish inner hair cell (IHC) from auditory-nerve (AN) dysfunction. In R. Goldfarb (Ed.). Translational Studies in Speech Pathology and Audiology: Essays in Honor of Dr. Sadanand Singh (2012).
  • Cacace, A. T., and McFarland, D. J. Single and double dissociations as a frame-of-reference: Application to auditory processing disorders (APDs). In R. Goldfarb (Ed.). Translational Studies in Speech Pathology and Audiology: Essays in Honor of Dr. Sadanand Singh, pp. 179-184 (2012).
  • McFarland, D. J., and Cacace, A. T. Establishing the construct validity of the auditory processing disorder (APD): Application of psychometric theory to clinical practice. In R. Goldfarb (Ed.). Translational Studies in Speech Pathology and Audiology: Essays in Honor of Dr. Sadanand Singh, 185-191 (2012).
  • Cacace, A.T., and McFarland, D.J. Middle latency auditory evoked potentials. In: J. Katz, editor, Handbook of Clinical Audiology, 7th Edition, (2014) (2014).
  • Tyler, R. S., Tao, P., and Cacace, A. T. The neural mechanisms of tinnitus. In: Tyler, R. S. (Editor), The Consumer Handbook of Tinnitus, pp. 31-47. Sedona, AZ: Auricle Ink Publishers (updated; 2014).
  • Cacace, A. T., and Burkard, R. F. The Audiogram: What it measures, what it predicts, and what it misses. In: Cacace, A. T., de Kleine, E., Holt, A. G., van Dijk, P. (Eds.), Scientific Foundations of Audiology: Perspectives from Physics, Biology, Modeling, and Medicine. San Diego: Plural Publishing, (2016), pp. 57-71.
  • McFarland, D. J., and Cacace, A. T. Theoretical considerations in developing an APD construct: A neuroscience perspective. In: Cacace, A. T., de Kleine, E., Holt, A. G., van Dijk, P. (Eds.), Scientific Foundations of Audiology: Perspectives from Physics, Biology, Modeling Processing Disorder (CAPD)., and Medicine. San Diego, Plural Publishing, (2016), pp. 321-330.
  • Cacace, A. T., Holt, A. G., Bergqvist, M., Castracane, J., Dixon, A., Curley, S., Apawu, A.K. Can we develop a silver “nano-bullet” for tinnitus? Practical and theoretical implications of a nanotheranostic framework. In: Rahman, A. U. (Ed.). Frontiers in Clinical Drug Research-CNS and Neurological Disorders, Bentham Scientific Publishers (In press, 2017).
     

Other Publications (since 2007):

  • Cacace, A. T. and Silver, S. M. Using magnetic resonance spectroscopy to understand the causes of tinnitus. Tinnitus Today, 32: (March) 14-15 (2007).
  • Cacace, A. T. Aging, Alzheimer’s disease, and hearing impairment: Highlighting relevant issues and calling for additional research. Am. J. Audiol. 16: 2-3 (2007).
  • Lee, S. L., Abraham, M., Cacace, A. T., and Silver, S. M. Repetitive transcranial magnetic stimulation in veterans with debilitating tinnitus, a pilot study. Amer. J. Otolaryngol. Head Neck Surg. 138: 398-399 (2008).
  • Romero, S. G., McFarland, D. J., Faust, R., Farrell, L., and Cacace, A. T. Electrophysiological markers of skill-related neuroplasticity. J. Biol. Psychol. 78: 221-230 (2008).
  • Cacace, A.T., and Pinheiro, J.M.B. The mitochondrial connection in auditory neuropathy. Audiol. Neuro-Otol. 16: 398-413 (2011).
  • McFarland, D. J., and Cacace, A. T. Covariance is the proper measure of test-retest reliability. Clin. Neurophysiol. 122:1893 (2011).
  • Lawfield, A., McFarland, D. J., and Cacace, A. T. Dichotic and dichoptic digit perception in normal adults. J. Amer. Acad. Audiol. 22: 332-341 (2011).
  • Carpenter, M. S., Cacace, A. T., and Mahoney, M. J. Missing links in some curious auditory phenomena: a tale from the middle ear. J. Amer Acad. Audiol. 23: 106-114 (2012).
  • Humes, L., Dubno, J., Gordan-Salant, S., Lister, J., Cacace, A.T., Cruickshanks, K., Gates, G., Wilson, R., Wingfield, A. Central presbycusis: A review and evaluation of the evidence. J. Amer Acad. Audiol. 23, 635-666 (2012).
  • Landegrebe, M., Azevedo A, Baguley D, Bauer C, Cacace A. T., Coelho C, et al. Clinical aspects of clinical trials in tinnitus: A proposal for an international standard. J. Psycho. Med. 73, 112-1121 (2012).
  • McFarland, D.J., and Cacace, A. T. Questionable reliability of the speech-evoked auditory brainstem response (sABR) in typically-developing children. Hear. Res. 287, 1-2 (2012).
  • Mahoney, M. J., McFarland, D. J., Carpenter, M. S., Cacace, A. T. Reliability of broadband middle-ear power-reflectance measures in younger and older adults: Application of Generalizability Theory. Amer. J. Audiol. 22, 241-251 (2013).
  • Cacace, A. T., McFarland, D. J. Factors influencing tests of central auditory processing: A perspective on current issues and relevant concerns. J. Amer. Acad. Audiol. 24, 572-589 (2013).
    Benson, R., Gattu, R., Cacace, A. T. Left hemisphere fractional anisotropy increase in noise-induced tinnitus: A diffusion tensor imaging (DTI) study of white matter tracts in the brain. Hear Res. 309, 8-16 (2014).
  • Roberts, L., Cacace, A.T. Jendrassik maneuver facilitates cVEMP amplitude: Some preliminary observations. J. Amer. Acad. Audiol. 25, 237-243 (2014).
  • Cacace, A.T., Brozoski, T., Berkowitz, B., Bauer, C., Castracane, J., Berkvist, M. Zhang, J., Holt, AG. Manganese enhanced MRI: A powerful new imaging method to study tinnitus. Hear Res. 311, 49-62 (2014).
  • Cacace, A. T., McFarland, D. J. Modality specificity trumps other methods for diagnosing the auditory processing disorder (APD): Response to Dillon et al. J Am Acad Audiol. 25, 703-705 (2014).
  • McFarland, D. J., Cacace, A. T. Modality specificity is the preferred method for diagnosing the auditory processing disorder (APD): Response to Moore and Ferguson. J Am Acad Audiol. 25, 698-699 (2014).
  • Cacace, A. T., McFarland, D. J. Lack of a coherent theory limits the diagnosis and prognostic value of the central auditory processing disorder (CAPD). J. Acoust. Soc. Amer. 136, 2258 (2014).
  • Tyler, R. S., Pienkowski, M., Roncancio, E. R., Jun, H. J., Brozoski, T., Dauman, N., Coelho, C. B., Anderrson, G., Keiner, A. J., Cacace, A., Martin, N., Moore, B. C. J. A review of hyperacusis and future directions: Part I. Definition and manifestations. Am. J. Audiol. 23, 402-419 (2014).
  • Pienkowski, M., Tyler, R. S., Roncancio, E. R., Jun, H. J., Brozoski, T., Dauman, N., Coelho, C. B., Anderrson, G., Keiner, A. J., Cacace, A., Martin, N., Moore, B. C. J. A Comprehensive Review of Hyperacusis and Future Directions: Part II. Measurement, Mechanisms, and Treatment. Am. J. Audiol. 23, 420-436 (2014).
  • Gattu, R., Akin, F. W., Cacace, A. T., Murnane, O., Haacke, E. M. Vestibular, balance, microvascular and white matter neuroimaging characteristics of blast injuries and mild traumatic brain injury: Four case reports. Brain Trauma 30, 1501-1514 (2016).
     

 

 

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