Selected Publications:

  • A Fully Synthetic Self-Adjuvanting Globo H-Based Vaccine Elicited Strong T Cell-Mediated Antitumor Immunity, Z. Zhou, G. Liao, S. S. Mandal, S. Suryawanshi, and Z. Guo, Chem. Sci., 2015, 6, 7112.

            

  • Cell Surface GPI Anchor Metabolic Engineering: A New Tool for the Study of Cell Surface GPI-Anchored Proteins, L. Lu, J. Gao, and Z. Guo, Angew. Chem. Int. Ed., 2015, 54, 9679.

  • Transbilayer Lipid Interactions Mediate Nanoclustering of Lipid-Anchored Proteins, R. Raghupathy, A. A. Anilkumar, A. Polley, P. P. Singh, M. Yadav, C. Johnson, S. Suryawanshi, V. Saikam, S. D. Sawant, A. Panda, Z. Guo, R. A. Vishwakarma, M. Rao, and S. Mayor, Cell, 2015, 161, 581.

             

  • ­­­­­Chemical Synthesis of the Repeating Unit of Type Ia Group B Streptococcus Capsular Polysaccharide, P. K. Mondal, G. Liao, M. A. Mondal, Z. Guo, Org. Lett., 2015, 17, 1102.

  • A Novel Cancer Immunotherapy Based on the Combination of a Synthetic Carbohydrate-Pulsed Dendritic Cell Vaccine and Glycoengineered Cancer Cells, L. Qiu, J. Li, S. Yu, Q. Wang, Y. Li, Z. Hu, Q. Wu, Z. Guo, J. Zhang, Oncotarget, 2015, 6, 5195.

  • Synthesis and Immunological Studies of Linear Oligosaccharides of β-Glucan as Antigens for Anti-Fungal Vaccine Development, G. Liao, Z. Zhou, S. Burgula, J. Liao, C. Yuan, Q. Wu, and Z. Guo, Bioconjugate Chem., 2015, 26, 466.

      

  • Synthesis and Evaluation of Monophosphoryl Lipid A Derivatives as Fully Synthetic Self-Adjuvanting Glycoconjugate Cancer Vaccine Carriers, Z. Zhou, M. Mondal, G. Liao and Z. Guo, Org. Biomol. Chem., 2014, 12, 3238.

  • Synthesis of a Minature Lipoarabinomannan, J. Gao, G. Liao, L. Wang and Z. Guo, Org. Lett., 2014, 16, 988.

  • Sortase A-Mediated Chemoenzymatic Synthesis of Complex Glycosylphosphatidylinositol-Anchored Protein, Z. Wu, X. Guo, J. Gao, and Z. Guo, Chem. Commun., 2013, 49, 11689.

  •  Synthesis of a Tristearoyl Lipomannan via Pre-Activation-Based Iterative One-Pot Glycosylation, J. Gao and Z. Guo, J. Org. Chem., 2013, 78, 12717.

  •  Chemoenzymatic Synthesis of the Human CD52 and CD24 Antigen Analogs, Z. Wu, X. Guo, G. Gu, and Z. Guo, Org. Lett., 2013, 15, 5906.

  • A New Method for Site-Specific Modification of Liposomes with Proteins via Sortase A-Mediated Transpeptidation, Z. Wu, X. Guo, and Z. Guo, Bioconjugate Chem., 2012, 23, 650.

  •  Combining synthetic carbohydrate vaccines and cancer cell glycoengineering for effective cancer immunotherapy, L. Qiu, X. Gong, Q. Wang, J. Li, H. Hu, Q. Wu, J. Zhang, and Z. Guo, Cancer Immunol. Immunother., 2012, 61, 2045.

      

  • Carbohydrate-Monophosphoryl Lipid A Conjugates Are Fully Synthetic Self-Adjuvanting Cancer Vaccines Eliciting Robust Immune Responses in Mouse, Q. Wang, Zhifang Zhou, S. Tang and Z. Guo, ACS Chem. Biol., 2012, 7, 235.

  • Total Synthesis of a Glycosylphosphatidylinositol Anchor of the Human Lymphoctye CD52 Antigen, S. Burgula, B. M. Swarts and Z. Guo, Chem. Eur. J., 2012, 18, 1194.

  • Chemical Synthesis and Functionalization of Clickable Glycosylphosphatidylinositol Anchors, B. M. Swarts and Z. Guo, Chem. Sci., 2011, 2, 2342.

 

  • Sortase A-Catalyzed Peptide Cyclization for the Synthesis of Macrocyclic Peptides and Glycopeptides, Z. Wu, X. Guo and Z. Guo, Chem. Commun., 2011, 9218.

  • Synthesis of Glycosylphosphatidylinositol (GPI) Anchors Bearing Unsaturated Lipid Chains, B. M. Swarts and Z. Guo, J. Am. Chem. Soc., 2010, 132, 6648.

  • Sortase A-Catalyzed Transpeptidation of Glycosylphosphatidylinositol Derivatives for Chemoenzymatic Synthesis of GPI-Anchored Peptides/Proteins, Z. Wu, X. Guo, Q. Wang, B. M. Swarts, and Z. Guo, J. Am. Chem. Soc., 2010, 132,1567.

  • Sortase-Catalyzed Peptide-Glycosylphosphatidylinositol (GPI) Analog Ligation, X. Guo, Q. Wang, B. M. Swarts, and Z. Guo, J. Am. Chem. Soc., 2009, 131, 9878.

 

  • Synthesis and Antibacterial Activities of N-Glycosylated Derivatives of Tyrocidine A – a Macrocyclic Peptide Antibiotic, H. Hu, J. Xue, B. M. Swarts, Q. Wang, Q. Wu, and Z. Guo, J. Med. Chem., 2009, 52, 2052.

  • Synthetic and Immunological Studies of 5’-N-phenylacetyl sTn to Develop Carbohydrate-Based Cancer Vaccines and to Explore the Impacts of Linkage between Carbohydrate Antigens and Carrier Proteins, Q. Wang, S. A. Ekanayaka, J. Wu, J. Zhang, and Z. Guo, Bioconjugate Chem., 2008, 19, 2060.

  • Synthesis and Biological Evaluation of Sperm CD52 GPI Anchor and Derivatives as Binding Receptors of the Pore-Forming Toxin – CAMP Factor, X. Wu, Z. Shen, X. Zeng, S. Lang, M. Palmer, and Z. Guo, Carbohydr. Res., 2008, 343, 1718.

   

  • A Total Synthesis of OSW-1, J. Xue, P. Liu, Y. Pan, and Z. Guo, J. Org. Chem., 2008, 73, 157.

  • Efficient Glycoengineering of GM3 on Melanoma Cell and Monoclonal Antibody-Mediated Selective Killing of the Glycoengineered Cancer Cell, Q. Wang, J. Zhang, and Z. Guo, Bioorg. Med. Chem., 2007, 15, 7561.

  • Biomimetic Glycoliposomes as Nanocarriers for Targeting P-Selectin on Activated Platelets, J. Zhu, J. Xue, Z. Guo, L. Zhang, and R. E. Marchant, Bioconjugate Chem., 2007, 18, 1366.

            

  • Effective Metabolic Engineering of GM3 on Tumor Cells by N-Phenylacetyl-D-mannosamine, P. Chefalo, Y. Pan, N. Nagy, C. Harding, and Z. Guo, Biochemistry, 2006, 45, 3733.

            

  • Cap and capture-release techniques applied to solid-phase oligosaccharide synthesis, J. Wu and Z. Guo, J. Org. Chem. 2006, 71, 7067.

  • Solution-Phase Synthesis with Solid-State Workup of an O-Glycopeptide with a Cluster of Cancer-Related T Antigens, N. Shao and Z. Guo, Org. Lett., 2005, 7, 3589.

  • Synthesis of a Lipid Conjugate of SO3Lea and Its Enhancement on Binding of Liposome to Activated Platelets, F. Yan, J. Xue, J. Zhu, R. Marchant, and Z. Guo, Bioconjugate Chem., 2005, 16, 90.

    

  • Synthesis and Immunological Properties of N-Modified GM3 as Therapeutic Cancer Vaccines, Y. Pan, P. Chefalo, N. Nagy, C. Harding, and Z. Guo, J. Med. Chem., 2005, 48, 875.

  

  • Chemical Synthesis of the Skeleton Structure of Sperm CD52 – A GPI-Anchored Glycopeptide, N. Shao, J. Xue, and Z. Guo, Angew. Chem. Int. Ed., 2004, 43, 1569.

  • Convergent Synthesis of a GPI Containing an Acylated Inositol, J. Xue and Z. Guo, J. Am. Chem. Soc., 2003, 125, 16334.

  • First Total Synthesis of a GPI-Anchored Peptide, J. Xue, N. Shao, and Z. Guo, J. Org. Chem., 2003, 68, 4020.

  • Efficient Synthesis of Complex Glycopeptides Based on Unprotected Oligosaccharides, J. Xue, and Z. Guo, J. Org. Chem., 2003, 68, 2713.

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