About Kendall’s research:

 

My project is focused on the regulation of inositol biosynthesis. Inositol is a six-carbon cyclic ring made from glucose and a precursor to several essential signaling lipids, including: phosphoinositides, inositol phosphates, and inositol pyrophosphates. These molecules are stringently regulated, especially in neuronal tissues, and inositol dysregulation is a well-documented characteristic of neurological disorders. One such disorder of particular interest to me is bipolar disorder. Individuals with this condition experience debilitating mood swings ranging from depression to mania. 

 

One of the drugs used to treat bipolar disorder is valproate, which inhibits inositol biosynthesis. Inhibition is likely occurring through the inhibitory phosphorylation of myo-inositol-3-phosphatesynthase (MIPS), the rate-limiting enzyme of inositol synthesis. My goal is to identify and characterize this phosphoregulatory mechanism of MIPS.

 

 

More about Kendall:

 

I enjoy being active, including going on hikes, riding my bike, and playing sports. I also like playing games (card, board, party, etc.) and getting together with friends to simply chat and hang-out. I like improving and repairing things and adamantly believe in leaving things around me in better condition than how I found them.

 

 

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