Education

  • Hebei Normal University, Shijiazhuang HB, China, 1985 (B.S.)
  • Hebei Normal University, Shijiazhuang HB, China, 1985 (M.S.)
  • University of Fribourg, Fribourg FR, Switzerland, 1997 (Ph.D.)
  • Wayne State University, Detroit MI, USA, 2000 (Postdoc)

 

Faculty Appointments

  • 2006 – Present: Associate Professor, Department of Communication Sciences and Disorders, College of Liberal Arts & Sciences, Wayne State University
  • 2005 – Present: Associate Professor, Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine
  • 2000 – 2005: Assistant Professor, Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine
  • 1990 – 1993: Instructor, Department of Biology, Hebei Normal University, Shijiazhuang, China

 

Other Professional Positions

  • 2007 – Present: Assistant Research Director, Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine
  • 2007 – Present: Present Associate member in Department of Physiology, Wayne State University School of Medicine
  • 2006 – Present: Present Board member, Lions Hearing Institute of Michigan
  • 1997 – 2000: Research Associate, Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine
  • 1994 – 1997: Research Assistant, Institute of Physiology, University of Fribourg, Switzerland
  • 1988 – 1990: Teaching Assistant, Biology Department, Hebei Normal University, China

 

Awards and Honors

  • WSU President’s Translational Research Enhancement Award, 2008
  • Present Honorary Professor, School of Life Science, Hebei Normal University, 2001
  • Award of Excellent Scholar: Education Section of the Embassy of P.R. China in Switzerland, 1997
  • Fellowship Award of Swiss National Foundation for Scientific Research (FNRS), 1994 – 1997
  • Award of Excellence in Scientific Research and Teaching, Hebei Normal University, 1994

 

Research

Areas of Interest

  • Electrical stimulation to suppress tinnitus in animal and human models
  • Development of advanced auditory neural implants
  • Mechanisms of noise and blast-induced tinnitus

Overview of the Tinnitus and Auditory Neuroscience Research Lab | Lab Gallery

Back to Top

 

Selected Publications

Journal articles

  1. Zhang, J.S. and Guan Z.L. (2008) Modulatory effects of somatosensory electrical stimulation on neural activity of the dorsal cochlear nucleus of hamsters. J. Neurosci. Res. 86(5):1178-1187.
  2. Zhang JS, Guan ZL, Ramachandran V, Dunford J, Seidman M, Bowyer S, Jiang Q and Elisevich K (2008) Electrical Modulation of Tinnitus-Related Activity. Seminars in Hearing.
  3. Hoa, M., Guan, Z.L., Auner, G., and Zhang, J.S. (2008) Tonotopic properties in the inferior colliculus following multichannel electrical stimulation of the dorsal cochlear nucleus of guinea pigs. Otolaryngology-Head and Neck Surgery, 139:152-155.
  4. Godfrey DA, Mikesell NL, Godfrey TG, Fulcomer AB, Kong W, Godfrey MA, Kaltenbach JA, Zhang, JS (2008) Effects of high-intensity sound exposure on neurotransmitter chemistry in the central auditory system. Seminars in Hearing.
  5. Bowyer SM, Seidman MD, Moran JE, Mason KM, Jiang Q, Elisevich K, Zhang J, Tepley N. (2008) Coherence analysis of brain activity associated with Tinnitus. In:  Proceedings of the 16th International Conference on Biomagnetism.
  6. Seidman MD, De Ridder D, Elisevich K, Bowyer SM , Darrat I, Dria J, Stach B, Jiang Q,  Tepley N, Ewing J, Seidman M, Zhang J.  Direct Electrical Stimulation of Heschl's Gyrus for Tinnitus Treatment.  The Laryngoscope  2008, 118;(3):491-500.
  7. Zhang, J.S. and Guan Z.L. (2007) Pathways involved in somatosensory electrical modulation of dorsal cochlear nucleus activity. Brain Res. 1184:121-131.
  8. Kaltenbach, J.A. and Zhang, J.S. (2007) Intense sound induced plasticity in the dorsal cochlear nucleus of rats: Evidence for cholinergic receptor upregulation. Hear. Res. 226(1-2):232-43. 
  9. Zhang, J.S., Kaltenbach, J.A., Godfrey, D.A. and Wang, J. (2006) Origin of hyperactivity in the hamster dorsal cochlear nucleus following intense sound exposure. J. Neurosci. Res. 84:819-831.
  10. Kaltenbach, J.A., Zhang, J.S. Finlayson, P. (2005) Tinnitus as a plastic phenomenon and its possible neural underpinnings in the dorsal cochlear nucleus. Hear. Res. 206(1-2):200-26.
  11. Kaltenbach J.A. and Zhang J.S. (2004) In vivo optical imaging of tone-evoked activity in the dorsal cochlear nucleus using voltage sensitive dye. J. Neurosci. Res., 78(6):908-917.
  12. Kaltenbach J.A., Zacharek M.A., Zhang J.S. and Frederick S. (2004) Recordings of activity in the dorsal cochlear nucleus of hamsters previously tested for tinnitus following intense sound exposure. Neurosci. Lett., 355:121-125.
  13. Zhang J.S., Kaltenbach J.A., Wang J. and Kim S.A. (2003) Fos-like immunoreactivity (FLI) in auditory and non-auditory brain structures of hamsters previously exposed to intense sound exposure. Exp. Brain. Res., 153:655-600.
  14. Zhang J.S., Kaltenbach J.A., Wang J. and Bronchti G. (2003) Changes in [14C]-2-deoxyglucose uptake in the auditory pathway of hamsters previously exposed to intense sound exposure. Hear. Res., 185:13-21.
  15. Chen, Y.M., Zhang, J.S, Duan, X.L. (2003) Changes of microvascular architecture, ultrastructure and permeability of rat jejunal villi at different ages. World J. Gastroenterol., 9: 795-799.
  16. Zacharek, M.A., Kaltenbach, J.A., Mathog, T. A. and Zhang, J.S. (2002) Effects of cochlear ablation on noise induced hyperactivity in the hamster dorsal cochlear nucleus: implications on the origin of noise-induced tinnitus. Hear. Res., 172: 137-144.
  17. Kaltenbach, J.A., Rachel, J.D., Mathog, T.A., Zhang, J.S., Falzarano, P.R. and Lewandowski, M. (2002) Cisplatin-induced hyperactivity in the dorsal cochlear nucleus and its relation to outer hair loss: implications for an understanding of tinnitus. J. Neurophysiol., 88: 699-714.
  18. Chang, H., Chen, K., Kaltenbach, J.A., Zhang, J.S. and Godfrey, D.A. (2002) Effects of acoustic trauma on dorsal cochlear nucleus neuron activity in slices. Hear. Res., 164: 59-68.
  19. Bahu, S., Kaltenbach, J.A., Zhang, J.S., Khariwhala, S., Afman, C. and Hnatiuk M. (2001) Expression of c-fos in the dorsal cochlear nucleus as a function of stimulus frequency in the hamster. Neurosci. Res. Comm., 29: 107-117.
  20. Zhang, J.S. and Kaltenbach, J.A. (2000) Modulation of spontaneous activity by muscarinic receptors in the rat dorsal cochlear nucleus in vivo.  Hear. Res., 140: 7-17.
  21. Kaltenbach, J.A., Zhang, J.S. and Afman, C.E. (2000) Plasticity of spontaneous neural activity in the dorsal cochlear nucleus after intense sound exposure. Hear. Res.,147: 282-292.
  22. Godfrey, D.A., Mikesell, N.L., Godfrey, T.G., Fulcomer, A.B., Kong, W., Godfrey, M.A., Zhang, J.S. and Kaltenbach, J.A. (1999) Chemistry in the hamster dorsal cochlear nucleus after loud tone exposure,” Proc. VIth Intl. Tinn. Sem., 6: 203-208.
  23. Chen, K., Chang, H., Zhang, J.S., Kaltenbach, J.A. and Godfrey, D.A. (1999) Altered spontaneous activity in rat dorsal cochlear nucleus following loud tone exposure. Proc. VIth Intl. Tinn. Sem., 6: 212-217.
  24. Zhang, J.S. and Kaltenbach, J.A. (1998) Increases in spontaneous activity in the dorsal cochlear nucleus of the rat following exposure to high intensity sound. Neurosci. lett., 250: 197-200.
  25. Kaltenbach, J.A., Godfrey, D.A., Neumann, J.B., McCaslin, D.L., Afman, C.E. and Zhang, J.S. (1998) Changes in spontaneous neural activity in the dorsal cochlear nucleus following exposure to intense sound: independents from threshold shift. Hear. Res., 124: 78-84.
  26. Haenggeli, A., Zhang, J.S., Vischer, M.W., Pelizzone, M. and Rouiller, E.M. (1998) Electrically evoked compound action potential (ECAP) of the cochlear nerve in response to pulsatile electrical stimulation of the cochlea in the rat: effects of stimulation at high rates. Audiology, 37: 353-371.
  27. Zhang, J.S., Vischer, M.W., Moret, V., Roulin, C. and Rouiller, E.M. (1998) Antibody-dependent Fos-like immunoreactivity (FLI) in the auditory pathway of the rat in response to electric stimulation of the cochlea. J. Brain Res., 39(1): 21-35.
  28. Vischer, M.W., Haenggeli, A., Zhang, J.S., Pelizzone, M., Häusler, R. and Rouiller, E.M. (1997) Effects of high-frequency electrical stimulation of the auditory nerve in an animal model of cochlear implants. Am. J. Otol., 18: S27-S29.
  29. Vischer, M.W., Bajo, V., Zhang, J.S., Calciati, E., Haenggeli, A. and Rouiller, E.M. (1997) Single unit activity in the inferior colliculus of the rat elicited by electrical stimulation of the cochlea. Audiology, 36: 202-227.
  30. Haenggeli, A., Vischer, M.W., Zhang, J.S., Pelizzone, M. and Rouiller, E.M. (1996) Animal model of cochlear implant and CIS strategy. Aktuelle Probleme der Otorhinolaryngologie, ORL, 19: 211-217.
  31. Zhang, J.S., Haenggeli, A., Tempini, A., Vischer, M.W., Moret, V. and Rouiller, E.M. (1996) Electrically induced Fos-like immunoreactivity (FLI) in the auditory pathway of the rats: effects of survival time, duration and intensity of stimulation. Brain Res. Bullet., 39 (2): 75-82.
  32. Vischer, M.W., Bajo, V., Zhang, J.S., Häusler, R. and Rouiller, E.M. (1995) Activity elicited in the auditory pathway of the rat by electrical stimulation of the cochlea. J. Oto-Rhino-Laryngol., 57: 305-309.
  33. Book chapters:
  34. Kaltenbach, J.A., Zhang, J.S., Zacharek, M.A. (2004) Neural correlates of tinnitus. In: Tinnitus: Theory and Management. Edited by J.B.Snow B.C. Decker Publishers, Inc., pp 141-161.
  35. Kaltenbach, J.A., Heffner, H.E., Zhang, J.S., Mathog, T.A. and Zacharek, M.A. (2001) Neurophysiological mechanisms of noise-induced tinnitus, Chapter 23, Noise Induced Hearing Loss: Basic Mechanisms, Prevention and Control, Henderson, D., Prasher, D., Kopke, R., Salvi, R., Hamernik, R. (Eds.), NRN Publications, London, pp.153-168.
  36. Zhang, J.S., Vischer, M.W., Haenggeli, C.A. and Rouiller, E.M. (1997) Responses of the auditory nerve to high rate pulsatile electrical stimulation: comparison between normal and deafened rats, Chapter 53, In: Acoustical Signal Processing in the Central Auditory System, Syka, J. (Ed.), Plenum Press, New York, pp. 577-583.
  37. Zhang, J.S. (1995) The psychophysiological principles of vocal music arts, Chapter 9, In: Vocal Music Course, Wang, M.J. (Ed.), People’s Music Press, Beijing, pp. 153-163.
  38. Zhang, J.S. and Sun, Z.Y. (1992) Sensory organs, Chapter 11, In: Test Questions and Answers of Human Histology and Anatomy, Duan, X.L. and Sun, Z.Y. (Ed.), Educational Science Press, Beijing, pp.129-138.

Back to Top

 

Mentoring Activity

Ph.D. Students

  • Virginia Ramachandran “Electrical suppression of tinnitus”. In progress.
  • Brian Murphy “Biocompatibility study of aluminum nitride electrodes”. (Co-mentored with Dr. Gregory Auner), completed 2008.

 

MD Residents Research Projects

  • Carron, Michael, M.D. “Noise-induced hyperactivity in the dorsal cochlear nucleus and its relation to outer hair cell loss: relevance to tinnitus”. Completed 2005.
  • Michael Hoa, M.D.  “Tonotopic properties in the inferior colliculus following multichannel electrical stimulation of the dorsal cochlear nucleus”. Completed 2006.
  • Johnny Mao, M.D.  “Blast-induced tinnitus and hearing loss”. Completed 2007.
  • Zacharek Mark, MD. “Effects of cochlear ablation on noise induced hyperactivity in the hamster dorsal cochlear nucleus: implications for the origin of noise induced tinnitus”. Completed 2002.
  • Bahu, Sam, M.D. “Expression of c-fos in the dorsal cochlear nucleus as a function of stimulus frequency in the hamster”. Completed 1999.
  • Kim, Alex, M.D. “Fos-like immunoreactivity (FLI) in auditory and non-auditory brain structures of hamsters previously exposed to intense sound exposure”. Completed 2000.
  • Rachel, John, M.D. “Cisplatin induced hyperactivity in the DCN: relation to outer hair cell loss”. Completed 1999.

 

Medical Students

  • Shkoukani, Mahdi “Neural response properties in the dorsal cochlear nucleus using ultra-speed real time optical imaging with voltage sensitive dyes”. 2005.
  • Darrat, Ilaaf  “Effects of conductive hearing loss on sound-induced hyperactivity in the dorsal cochlear nucleus”. 2004.
  • Lam, Chris “Cortical electrical modulation of neural activity in the inferior colliculus and dorsal cochlear nucleus”. 2007

 

Audiology graduate (Au.D.) Students

  • Laurau Suau “Electrical suppression of tinnitus related neural activity in the dorsal cochlear nucleus”, 2004.
  • Virginia Ramachandran “Optical imaging study of neural activity in the dorsal cochlear nucleus”, 2004-2005.
  • Paige Pierozynski “Investigation of noise/blast induced tinnitus using behavioral and imaging assays”, 2007- 2008.

Back to Top

 

Student Awards

Virginia Ramachandran, Student Grant Award (American Tinnitus Association)

Virginia Ramachandran, M.S.W., an Au.D./Ph.D. graduate student received a $10,000 research grant award from the American Tinnitus Association (ATA) in 2007.

The research proposal, entitled "Mechanisms Underlying Acoustic Masking of Tinnitus", will examine responses of neural correlates of tinnitus to acoustic stimulation in an animal model of tinnitus. The ATA is a primary national organization dedicated to curing tinnitus through advanced research and services and serves as a major source of funding for tinnitus research.

 

  

Jonathan Dunford, Best Poster Award (Del Hard Foundation)

Jonathan Dunford, a researchassistant, received a Best Student/Novice Poster award at the 2008 annual research day sponsored by the Del Harder Foundation.

This award came with a $250 check. His poster was entitled "Tonotopic properties in the inferior colliculus following multichannel electrical stimulation of the dorsal cochlear nucleus of rats”.

Dr. Jinsheng Zhang, Jonathan Dunford, Paige Pierozynski (from left)

 ↑ back to top